biomedmcp

Analyze an installed public cancer genomics study: gene_profile, mutation_cohort, survival, compare, co_occurrence, filter_cohort, top_mutated. List installed studies with get_capabilities(source=study); ubi_synthetic is invented demo data. Report sample denominators and exclusions. Private data analysis uses the Ubi platform. e.g. {"analysis":"gene_profile","study":"ubi_synthetic","gene":"TP53"}

Build a multi-section dossier in one call: verified identity, default record sections and top related papers, with citations and per-source outcomes. Workflows: target_dossier, model_input_bundle (gene), drug_review, disease_landscape, pathway_review, variant_dossier, negative_evidence (bounded literature check; never proves absence). Add sections with get_record. e.g. {"workflow":"target_dossier","focus":"LDLR","species":9606}

List records linked to one record. gene/drug/disease: articles, trials. variant: articles, structure. article: citations, references, recommendations, authors, entities. author: articles. Record attributes are get_record sections, not relations. e.g. {"entity":"article","id":"PMID:123","relation":"references"}

List enabled sources, entity sections, dossier workflows and source operations with exact parameter schemas. Narrow with source or entity; diagnose=true probes source health. Examples: biomedmcp://guide. e.g. {}

Show remaining research allowance and reset times; signed-in accounts get higher limits. e.g. {}

Fetch one record by ID with optional evidence sections, e.g. gene expression/eqtl/diseases/druggability, drug label/safety, article fulltext, trial eligibility, protein domains/structures. Variants: get_variant_evidence. List an entity's sections with get_capabilities(entity=...). e.g. {"entity":"gene","id":"PCSK9","species":9606}

Get evidence for one variant (rsID, gene + protein change, HGVS or chr:pos:ref:alt). Defaults: ClinVar, gnomAD population, CIViC; add predictions (AlphaMissense), eve, cosmic, oncokb, hotspots, gwas or cbioportal. Ambiguous assembly or transcript is reported, not guessed; predictions keep source and uncertainty. e.g. {"id":"PCSK9 R46L"}

Run a source-specific operation that other tools do not cover, e.g. ChEMBL bioactivities, Ensembl coordinates, PDB structure quality, OmniPath interactions, NCBI Datasets genomes, ncbi-records for GenBank/GEO/SRA. Read get_capabilities(source=...) for operations and params first. e.g. {"source":"gtex","operation":"get_metadata","params":{"info_type":"tissues","dataset_id":"gtex_v10"}}

Map a name, alias or ambiguous identifier to exact species-qualified IDs before joining evidence. Returns candidates when ambiguous; a provider match score alone is not identity. Skip when you already hold an exact ID. e.g. {"entity":"gene","query":"LDL receptor","species":9606}

Run up to ten independent read calls in parallel with one quota reservation; each result keeps its own outcome. build_dossier and utilities are not batchable. e.g. {"calls":[{"operation":"get_record","arguments":{"entity":"gene","id":"PCSK9","species":9606}}]}

Search papers across PubMed, Europe PMC, PubTator and LitSense with date, author, journal, article-type and open-access filters. Deduplicates across sources and reports each source's outcome. Read abstracts or full text with get_record(entity=article). e.g. {"query":"PCSK9 LDL cholesterol"}

Search genes, proteins, drugs, diseases, phenotypes, pathways, variants, pharmacogenomics, GWAS, diagnostics, adverse events, studies, patents or authors by text; returns IDs for get_record (variants: get_variant_evidence). Papers: search_literature. Trials: search_trials. Patent search is chemistry-linked (SureChEMBL); assignee/inventor/CPC search is query_source(source=patents). e.g. {"entity":"gene","query":"BRCA1","filters":{"species":9606}}

Search clinical trials (ClinicalTrials.gov, NCI) by condition, intervention, phase and recruitment status. Read arms, eligibility or outcomes with get_record(entity=trial). Does not assess an individual's eligibility. e.g. {"query":"familial hypercholesterolemia","filters":{"status":"RECRUITING"}}