三域医研 · 科研算法引擎 (SanYu Research Engine)

Academic language polishing / 中英文润色 | USE WHEN: the user wants a paragraph polished: academic English, remove Chinglish, tighten wording | ALIASES: 润色, 改英语, 中式表达, 语言润色, polish, proofread, 学术英语 | RETURNS: 润色后文本

Acceptance probability / 录用概率预测 | USE WHEN: the user asks the chance of acceptance at a specific journal | ALIASES: 中稿概率, 录用概率, 能中吗, acceptance, predict success, 投中的机会 | RETURNS: 中稿概率与依据

CRF 编码建议 用户问 CRF 字段该怎么编码、要不要用 CDASH MedDRA/WHO-DD 字段归类建议（哪些字段属 AE/CM、该用哪本字典、编到哪一层；不含术语级编码）

Animal dose & injection volume / 动物给药量计算 | USE WHEN: compute the dose (mg) and injection volume (mL) for an animal from body weight and mg/kg | ALIASES: 动物给药量, 给药体积, 按体重给药, dose volume, mg/kg, 注射体积, 灌胃体积 | RETURNS: 给药量与体积

Animal randomization / 动物随机分组 | USE WHEN: randomly assign animals to groups as required by ARRIVE | ALIASES: 动物随机分组, animal randomization, 分组表, 动物分组 | RETURNS: 分组表

Animal sample size (3R) / 动物实验样本量 | USE WHEN: how many animals per group are needed (power-based, ARRIVE/3R wording) | ALIASES: 动物样本量, 动物要多少只, 每组几只, animal sample size, 3R, power animals | RETURNS: 每组动物数

Animal survival analysis / 动物生存分析 | USE WHEN: Kaplan-Meier and log-rank on animal death/survival times | ALIASES: 动物生存分析, 生存曲线, log-rank, animal survival, KM, 死亡时间 | RETURNS: KM 曲线与 log-rank

ARRIVE 2.0 checklist / ARRIVE 2.0 检查 | USE WHEN: check an animal experiment against the ARRIVE 2.0 reporting guideline | ALIASES: ARRIVE, 动物实验规范, 动物伦理报告, animal reporting, ARRIVE 2.0 | RETURNS: ARRIVE 条目核对

ATAC-seq differential accessibility / ATAC 差异可及性 | USE WHEN: differential open regions from ATAC-seq counts | ALIASES: ATAC, 差异可及性, 染色质开放, differential accessibility, peak差异 | RETURNS: 差异 peak

Bioequivalence (BE) / 生物等效性评价 | USE WHEN: compare test vs reference AUC/Cmax and judge 80-125% bioequivalence with 90% CI | ALIASES: 生物等效性, BE, AUC Cmax, 90%CI, 等效性判定, bioequivalence | RETURNS: 90%CI 与等效性判定

Calibration curve (prediction model) / 校准曲线 | USE WHEN: assess calibration of a risk model and get the curve plus Brier score | ALIASES: 校准曲线, 校准度, Brier, calibration, 预测模型校准, 可靠性曲线 | RETURNS: 校准曲线与 Brier 分数

Cell assay calculator / 细胞实验通用计算 | USE WHEN: CCK8 / wound healing / Transwell / colony formation calculations (pick tool_id: cck8, wound-healing, transwell, colony) | ALIASES: CCK8, 划痕实验, Transwell, 克隆形成, 细胞增殖, 迁移实验, cell viability, wound healing | RETURNS: 计算结果

ChIP-seq peak calling / ChIP-seq Peak calling | USE WHEN: call peaks from ChIP-seq reads | ALIASES: ChIP-seq, peak calling, 峰识别, 转录因子结合, ChIP | RETURNS: peak 清单

Citation formatting / 引文格式化 | USE WHEN: reformat references to Vancouver / APA / GB-T 7714 | ALIASES: 参考文献格式, 引文格式, Vancouver, APA, GB/T 7714, citation, 文献格式 | RETURNS: 格式化后的引文

Verify citation authenticity / 引文真实性核验 | USE WHEN: check whether references are fabricated (existence check against the local corpus) | ALIASES: 核验参考文献, 引用是真的吗, 假文献, citation verify, 参考文献真实性, hallucinated reference | RETURNS: 逐条核验结果

Classification metrics / 分类性能报告 | USE WHEN: full diagnostic performance set: accuracy, sensitivity, specificity, PPV, NPV, F1 | ALIASES: 分类性能, 准确率, 敏感度, 特异度, PPV, NPV, confusion matrix, 诊断指标 | RETURNS: 分类指标全套

Molecular cloning design / 克隆方案设计 | USE WHEN: design a plasmid construct: homology arms, primers, assembly strategy | ALIASES: 分子克隆, 构建质粒, 同源臂, cloning, Gibson, 酶切连接, 引物设计克隆 | RETURNS: 克隆方案与引物

Compare two manuscript versions / 改稿前后对比 | USE WHEN: the user wants to know what changed between a before and after revision of the same passage | ALIASES: 改稿对比, 修改前后, 两版差异, compare revisions, diff, 版本对比 | RETURNS: 逐段差异与改进评估

CONSORT flow diagram / CONSORT 流程图 | USE WHEN: draw a CONSORT participant flow diagram from screening/randomization/loss counts | ALIASES: CONSORT流程图, 流程图, 入组流程, flow diagram, 筛选失访 | RETURNS: CONSORT 流程图

Cover letter / 投稿信 Cover Letter | USE WHEN: the user wants a cover letter to the journal editor | ALIASES: 投稿信, cover letter, 给编辑的信, 投稿说明 | RETURNS: 投稿信正文

CRF / SDTM validation / CRF 数据校验（SDTM） | USE WHEN: check whether CRF data meets CDISC SDTM conventions before export | ALIASES: CRF校验, SDTM, CDISC, 数据合规, 导出前检查, CRF validate, data standards | RETURNS: 校验结果

Parse pasted data / infer column types / 数据解析与列类型识别 | USE WHEN: the user pasted a CSV/table blob: get shape, column types, missingness before analysis | ALIASES: 解析数据, 列类型, 粘贴表格, CSV解析, parse data, column types, 数据形状 | RETURNS: 行列数、列类型、缺失情况

List data columns / 读取数据列名 | USE WHEN: list the variables in an uploaded data file (do this before Table 1 / modeling so you use real column names) | ALIASES: 列名, 有哪些变量, 字段名, columns, variables, 变量清单, 表头 | RETURNS: 列名与类型

Dataset profile / 数据快速画像 | USE WHEN: first look at a data file: distributions, missingness, outliers, data quality overview | ALIASES: 数据长什么样, 描述统计, 缺失情况, 数据质量, data profile, descriptive, summary stats, EDA | RETURNS: 描述统计与质量概览

Multi-option decision arbitration / 决策引擎裁决 | USE WHEN: the user must choose between several options or pipelines and wants a quantified ruling | ALIASES: 裁决, 取舍, 决策引擎, 多方案比较, arbitration, which option is better | RETURNS: 裁决结果与理由

Deep peer review (six dimensions) / 深度审稿（六维） | USE WHEN: the user wants reviewer-grade deep comments, as if reviewed by a strict peer reviewer | ALIASES: 深度审稿, 模拟审稿人, 严格审稿, deep review, reviewer comments | RETURNS: 深度审稿报告

De-identify text (HIPAA 18 + China national ID) / 数据脱敏 | USE WHEN: the user needs patient text de-identified before sharing: names, dates, phone, ID number, MRN | ALIASES: 脱敏, 去标识, 隐私, HIPAA, PHI, 匿名化, deidentify, anonymize | RETURNS: 脱敏后文本

DeLong test (compare two AUCs) / 两条 ROC 的 AUC 比较（DeLong） | USE WHEN: compare two ROC AUCs from the same subjects and test whether the difference is significant | ALIASES: DeLong, 两个AUC比较, 哪个指标更好, AUC差异, compare AUC, 曲线下面积比较 | RETURNS: 两 AUC 及差值 P 值

Design gate rules / 方案设计闸门规则 | USE WHEN: explain why a design step is blocked, or what the platform requires for each step (hard gates G1/G2/G3) | ALIASES: 方案设计闸门, 为什么不让过, 硬性要求, gate rules, validation rules, why blocked | RETURNS: 每步是否有硬闸门、三道跨步闸门 G1/G2/G3 的原文规则

Full research protocol generation / 完整研究方案 / 方案设计工具 | USE WHEN: the user wants a complete research protocol including sample size, statistical plan and ethics points | ALIASES: 研究方案, 方案正文, 写方案, 方案生成, protocol, full protocol | RETURNS: 完整研究方案 JSON（14 段）或单项工具结构化结果；缺参时返回 needs_user_input 明确列出缺什么，不返回编造值

Design step context / 取某一步的上下文 | USE WHEN: load what the user already answered for a design step (PICO / design type / population) before drafting the next step | ALIASES: 方案设计上下文, 上一步内容, 已经填过的信息, design context, previous step, project context | RETURNS: 该步骤可用的前序上下文（pico / design_type / population / topic）

Study design decision / 研究设计决策推荐 | USE WHEN: the user asks which study design to use (RCT vs cohort etc.) and why; rule-based decision tree with a scoring matrix, not LLM guessing | ALIASES: 用什么设计, RCT还是队列, 设计决策, 选哪个设计, design decision, which design type | RETURNS: 推荐设计类型、框架、推荐依据、分配比例

Differential expression (limma-style) / 差异表达分析 | USE WHEN: differential genes from an expression matrix (with volcano plot input) | ALIASES: 差异表达, 差异基因, DEG, differential expression, 火山图, 表达矩阵, limma | RETURNS: 差异基因清单（log2FC、t 统计量、p_value、BH-FDR 校正后的 padj、显著/上调/下调标记）

Distribution goodness-of-fit / 分布拟合检验 | USE WHEN: the user asks whether the data are normally distributed or which distribution fits (normality / goodness-of-fit test) | ALIASES: 分布拟合, 正态性检验, 是不是正态, 服从什么分布, KS检验, Shapiro, distribution fit, goodness of fit, normality test | RETURNS: 拟合优度

DNA → protein translation / 序列翻译 | USE WHEN: translate a nucleotide sequence into amino acids in all three frames | ALIASES: 序列翻译, 核酸转蛋白, 翻译, translate, DNA to protein, 氨基酸序列, ORF翻译 | RETURNS: 氨基酸序列

Drug-drug interaction check / 药物相互作用检查 | USE WHEN: can these two drugs be used together? interaction severity and mechanism | ALIASES: 药物相互作用, 能不能一起用, 配伍禁忌, DDI, drug interaction, 相互作用 | RETURNS: 相互作用等级与机制

Dunn post-hoc test / 多组非参数两两比较（Dunn） | USE WHEN: pairwise comparisons after Kruskal-Wallis (nonparametric, multiple groups) | ALIASES: Dunn, 非参数两两比较, Kruskal-Wallis后续, post hoc, 多重比较 | RETURNS: 两两比较 P 值

Egger's test (publication bias) / Meta 发表偏倚（Egger） | USE WHEN: test publication bias in a meta-analysis and get funnel-plot inputs | ALIASES: Egger, 发表偏倚, 漏斗图, publication bias, meta回归, funnel plot | RETURNS: Egger 检验 P 与截距

Evidence follow-up Q&A / 证据追问（多轮） | USE WHEN: multi-turn follow-up on an evidence card (causal judgement) | ALIASES: 证据追问, 继续追问, 证据卡, evidence followup, 因果判断 | RETURNS: 追问答复

Structured evidence intake / 文献证据分级录入 | USE WHEN: decompose a paper into a structured evidence card by evidence level (Decision OS) | ALIASES: 证据分级, 证据卡, 文献拆解, evidence level, GRADE, 证据录入 | RETURNS: 结构化证据卡

Evidence report narrative / 证据报告叙述 | USE WHEN: turn evidence cards into a readable report | ALIASES: 证据报告, 证据综述, evidence report, 证据叙述 | RETURNS: 证据报告正文

Bench experiment plan / 实验方案生成 | USE WHEN: the user needs an animal or cell experiment plan (basic research) | ALIASES: 实验方案, 动物实验, 细胞实验, 基础实验设计, experiment plan, bench work plan | RETURNS: 实验方案

Liver fibrosis staging / 纤维化分期 | USE WHEN: map fibrosis scores to Ishak / METAVIR stage | ALIASES: 纤维化分期, Ishak, METAVIR, 肝纤维化, fibrosis stage, 病理分期 | RETURNS: 分期结论与解读

Figure legend writer / 图注生成 | USE WHEN: write a figure legend for a given chart type | ALIASES: 图注, Figure legend, 图片说明, 图例, 写图注 | RETURNS: 图注文本

Flow cytometry clustering / 流式细胞聚类 | USE WHEN: unsupervised clustering of flow cytometry data into cell populations | ALIASES: 流式聚类, 无监督分群, flow clustering, 细胞群, FlowSOM | RETURNS: 细胞群与比例

Flow cytometry gating / 流式门控分析 | USE WHEN: gating / population percentages from flow cytometry data | ALIASES: 流式门控, 圈门, gating, 阳性比例, flow cytometry | RETURNS: 门控比例

Forest plot / 森林图 | USE WHEN: forest plot from HR/OR/RR with confidence intervals | ALIASES: 森林图, forest plot, HR OR RR, 置信区间图, meta森林图 | RETURNS: 森林图（矢量）

Gene information lookup / 基因信息检索 | USE WHEN: what a gene does: full name, aliases, function, location | ALIASES: 基因信息, 这个基因是干什么的, gene function, 别名, gene info, 基因全称 | RETURNS: 基因信息

Gene → pathway → disease network / 基因-通路-疾病网络 | USE WHEN: from a gene list, find pathway / disease / drug associations and build a mechanism network | ALIASES: 基因通路, 机制网络, gene pathway, 疾病关联, 药物靶点, network, 通路疾病 | RETURNS: 通路/疾病/药物关联

GEO dataset pipeline / GEO 数据全流程 | USE WHEN: end-to-end on a GEO accession: DEG → enrichment → immune infiltration | ALIASES: GEO, GSE, 数据集分析, GEO编号, geo dataset, public data reanalysis | RETURNS: 差异基因、富集结果

Gleason grade group / Gleason 分级分组 | USE WHEN: Gleason score → Grade Group and risk stratum (prostate cancer) | ALIASES: Gleason, 前列腺癌分级, Grade Group, 格里森评分, 前列腺病理 | RETURNS: Grade Group 与风险分层

GO / KEGG enrichment / 通路富集（GO/KEGG） | USE WHEN: pathway enrichment for a gene list (GO biological process, KEGG) | ALIASES: 富集分析, GO, KEGG, 通路富集, enrichment, 通路, 功能注释 | RETURNS: 富集通路与 P 值

IC50 curve fitting / IC50 曲线拟合 | USE WHEN: fit a dose-response curve and report IC50 with 95% CI | ALIASES: IC50, 半数抑制浓度, 剂量效应曲线, dose response, 抑制率拟合, GI50 | RETURNS: IC50 值与 95%CI

Idea ignition / 想法点燃 | USE WHEN: the user gives one vague word or a hunch and wants it expanded into researchable directions | ALIASES: 想法, 一个词, 不知道研究啥, 灵感, 发散一下, idea, hunch, expand this idea | RETURNS: 扩展研究方向

IHC scoring (H-score / Allred) / IHC 免疫组化评分 | USE WHEN: immunohistochemistry scoring from staining intensity percentages (H-score, Allred, positive rate) | ALIASES: 免疫组化评分, H-score, Allred, IHC, 阳性率, 染色评分, ER PR HER2 | RETURNS: H-score / Allred / 阳性率

IPTW inverse probability weighting / IPTW 逆概率加权 | USE WHEN: propensity-score weighting (ATE/ATT) for observational comparisons | ALIASES: IPTW, 逆概率加权, 倾向评分加权, propensity weighting, 加权后效应, ATE | RETURNS: 权重与加权后效应

Journal recommendation / 智能选刊 V3 | USE WHEN: recommend target journals from title/abstract, in reach / match / safe tiers | ALIASES: 选刊, 投哪个期刊, 期刊推荐, journal, submission target, 冲稳保, 投稿建议 | RETURNS: 候选期刊与三档策略

Kaplan-Meier curve / Kaplan-Meier 曲线 | USE WHEN: KM curve and median survival only (no multivariable model) | ALIASES: KM曲线, Kaplan-Meier, 中位生存, 生存曲线, 生存率, log-rank | RETURNS: KM 曲线与中位生存

Linear mixed model (repeated measures) / 线性混合模型（纵向/重复测量，公式模式） | USE WHEN: same subject measured repeatedly (pre/post, multiple follow-ups): compare trajectories over time, group×time interaction; modern replacement for repeated-measures ANOVA (handles missing, no sphericity assumption) | ALIASES: 混合模型, 重复测量, 纵向数据, LMM, mixed model, 交互作用, 多次随访, 每人测多次, repeated measures | RETURNS: 固定效应系数/SE/Wald z/P/95%CI（按真实变量名，不是 X1/X2）、各项整体检验 omnibus、交互项检验、primary_test、ICC、方差成分、n_subjects/n_obs、组间例数、缺失与收敛告警

List the caller's uploaded data files / 列出我的数据文件 | USE WHEN: the user asks what data files they have uploaded / available in the workspace | ALIASES: 我的数据, 已上传文件, 数据文件列表, my data, list files | RETURNS: 数据文件列表（含 file_id/文件名/行数）

Compare with published literature / 与已有文献对比 | USE WHEN: the user wants to know how their findings differ from what is already published | ALIASES: 和文献比, 新在哪, 对比已有研究, literature compare, how is this different | RETURNS: 对比结论

Literature digest card / 文献摘要卡生成 | USE WHEN: the user gives a paper and wants a structured digest card out of it | ALIASES: 摘要卡, 文献卡片, 精读卡, digest, literature card | RETURNS: 摘要卡

Review outline from reading list / 文献综述提纲 | USE WHEN: the user wants a review outline built from the papers already digested | ALIASES: 综述提纲, review outline, 按精读文献出提纲 | RETURNS: 综述提纲

Literature search (1.53M PMC full texts) / 文献检索（站内 153 万篇 PMC） | USE WHEN: search the in-house PMC corpus for literature / evidence / state of the art | ALIASES: 找文献, 文献检索, 检索文献, literature search, PMC, 证据, 研究现状, PubMed替代 | RETURNS: 文献列表（含 PMCID）

Local literature comparison / 本地文献对比 | USE WHEN: the user gives a topic and wants a cross-comparison table of the in-house literature | ALIASES: 本地文献对比, 横向对比, 文献对比表, local literature compare | RETURNS: 对比表

Mermaid diagram generation / 生成流程图（Mermaid） | USE WHEN: the user wants a flow chart, sequence diagram or mind map expressed as Mermaid code | ALIASES: 流程图, Mermaid, 时序图, 思维导图, 画流程, diagram, flowchart | RETURNS: Mermaid 代码

Metabolite heatmap / 代谢组热图 | USE WHEN: clustered heatmap of metabolites | ALIASES: 代谢热图, 聚类热图, heatmap, metabolite heatmap | RETURNS: 聚类热图

Metabolite pathway enrichment / 代谢物通路富集 | USE WHEN: pathway enrichment for differential metabolites | ALIASES: 代谢物通路, 代谢富集, metabolite pathway, KEGG代谢, 差异代谢物 | RETURNS: 代谢通路富集

Metabolite PCA / 代谢组 PCA | USE WHEN: sample separation / outliers in metabolomics (unsupervised) | ALIASES: 代谢组PCA, PCA, 样本分组趋势, 离群, unsupervised, 得分图 | RETURNS: PCA 得分与解释度

Metabolite PLS-DA / 代谢组 PLS-DA | USE WHEN: supervised discrimination and VIP for differential metabolites | ALIASES: PLS-DA, 有监督判别, VIP, 代谢组判别, 判别分析 | RETURNS: PLS-DA 模型与 VIP

Metabolite volcano plot / 代谢组火山图 | USE WHEN: volcano plot of differential metabolites | ALIASES: 代谢火山图, volcano, 差异代谢物火山图 | RETURNS: 火山图

Multiplex IF phenotyping / 多重免疫荧光表型 | USE WHEN: assign cell phenotypes and proportions from multiplex immunofluorescence markers | ALIASES: 多重免疫荧光, mIF, 细胞表型, phenotype, marker组合, 亚群比例 | RETURNS: 细胞亚群表型与比例

Multi-omics integration / 多组学整合 | USE WHEN: integrate mRNA / protein / metabolite layers and find cross-layer associations | ALIASES: 多组学, 整合分析, multi-omics, 转录组蛋白组代谢组, cross-omics | RETURNS: 多组学关联结果

Nomogram / 列线图 Nomogram | USE WHEN: turn a logistic or Cox model into a nomogram figure for clinical use | ALIASES: 列线图, Nomogram, 评分图, nomogram, 风险评分图 | RETURNS: 列线图 SVG

NSFC grant fit analysis / 国自然申报分析 | USE WHEN: the user asks whether a topic fits NSFC / provincial funding, which category, and the odds | ALIASES: 国自然, NSFC, 基金申报, 省自然, 命中率, 报什么口子, grant fit | RETURNS: 国自然分析

Nuclei segmentation & counting / 细胞核分割与计数 | USE WHEN: cell density / positive rate from a tissue section (nuclei segmentation) | ALIASES: 细胞核分割, 细胞计数, 密度, nuclei count, segmentation, 阳性细胞率 | RETURNS: 分割统计结果

Multi-omics methods section draft / 多组学论文段落 | USE WHEN: the user wants a methods section for a multi-omics paper, assembled only from the analyses they actually ran | ALIASES: 多组学方法, 方法学段落, RNA-seq 方法, methods section, omics methods | RETURNS: 论文段落

ORF prediction / ORF 预测 | USE WHEN: find open reading frames in a nucleotide sequence | ALIASES: ORF, 开放阅读框, 找编码区, open reading frame, 翻译起始 | RETURNS: ORF 列表与位置

Organ coefficient / 脏器系数 | USE WHEN: organ weight / body weight ratio (脏器系数) | ALIASES: 脏器系数, 器官系数, organ coefficient, organ index, 脏器重量比 | RETURNS: 脏器系数

Manuscript outline / 生成论文提纲 | USE WHEN: the user wants the outline / chapter structure before the full text is written | ALIASES: 提纲, 目录, 章节结构, 论文框架, outline, chapter structure | RETURNS: 章节提纲

Six-agent manuscript review / 论文预审（六智能体） | USE WHEN: the user wants a pre-submission review to find the reasons a paper would be rejected | ALIASES: 预审, 六智能体, 审稿意见, 投稿前审, manuscript review, six agent review | RETURNS: 审稿意见与评分

PCR primer design / PCR 引物设计 | USE WHEN: design PCR primer pairs from a DNA sequence or gene (Tm, GC, product size) | ALIASES: 引物设计, PCR引物, primer, 设计引物, 扩增引物, primer pair | RETURNS: 候选引物对与 Tm/GC

PICO from pasted text / 从文本抽取 PICO | USE WHEN: the user pastes an abstract or paragraph and wants PICO extracted from it | ALIASES: 抽取PICO, 从摘要提PICO, 文献PICO, extract pico from text | RETURNS: 结构化 PICO

Permutation test / 置换检验 | USE WHEN: exact/permutation test when t-test assumptions fail or n is tiny | ALIASES: 置换检验, 随机化检验, permutation, 精确检验, 小样本非参数, resampling | RETURNS: 置换 P 值

PICO refinement / PICO 精炼 | USE WHEN: turn a vague clinical question into a structured PICO (Population / Intervention / Comparator / Outcome) | ALIASES: PICO, 把问题拆开, 研究问题怎么提, refine question, 结构化问题, PICO拆解 | RETURNS: 结构化 PICO

PICO structuring (design flow) / PICO 结构化精炼 | USE WHEN: the user says refine my PICO / turn this sentence into PICO / how to split PICO; only structures what the user said and reports missing elements instead of inventing them | ALIASES: 精修PICO, PICO拆解, 做成PICO, 结构化PICO, pico refine, structure pico | RETURNS: PICO 四要素结构化结果 + 提示缺哪些要素

Non-compartmental PK (NCA) / NCA 非房室药代分析 | USE WHEN: non-compartmental analysis of concentration-time data: AUC, Cmax, Tmax, t1/2, CL, Vd | ALIASES: NCA, 非房室分析, 药代参数, AUC Cmax T1/2, PK parameters, 血药浓度 | RETURNS: AUC/Cmax/Tmax/T1/2/CL/Vd

PK/PD assessment / PK/PD 评估 | USE WHEN: pharmacokinetic/pharmacodynamic assessment and dose projection | ALIASES: PK/PD评估, 药代药效, 剂量推算, pkpd assess, 暴露量 | RETURNS: PK/PD 评估结果

PK/PD simulation / PK/PD 模拟 | USE WHEN: simulate concentration-effect time course for a dosing regimen | ALIASES: PK/PD模拟, 给药方案模拟, 浓度时间曲线, simulation, 剂量方案 | RETURNS: 模拟曲线与参数

Plasmid map / 质粒图谱 | USE WHEN: draw/describe a plasmid map from a sequence (features, orientation) | ALIASES: 质粒图谱, 载体结构, plasmid map, vector, 质粒构建图 | RETURNS: 质粒图谱

Protein-protein interaction network / 蛋白互作网络 | USE WHEN: PPI network from a protein list, hub identification (STRING) | ALIASES: 蛋白互作, PPI, STRING, hub基因, 互作网络, network | RETURNS: 互作网络与 hub 蛋白

Pre-submission review / 投稿前预审 | USE WHEN: the user wants a pre-submission check to find likely rejection points | ALIASES: 投稿前预审, 会被拒吗, 投稿检查, pre review, desk reject risk | RETURNS: 预审意见

Primer Tm & dimers / 引物 Tm 计算 | USE WHEN: Tm, GC% and self/cross dimer check for given primer sequences | ALIASES: Tm, 引物Tm, 退火温度, GC含量, 二聚体, primer dimer, melting temperature | RETURNS: Tm、GC、二聚体

PRISMA flow diagram / PRISMA 流程图 | USE WHEN: PRISMA literature screening flow for systematic reviews / meta-analyses | ALIASES: PRISMA, 文献筛选流程, 系统评价流程图, flow diagram, 检索流程图 | RETURNS: PRISMA 流程图

Propensity score matching (PSM) / 倾向性评分匹配 PSM | USE WHEN: match treated and control subjects on baseline covariates (1:1 nearest neighbour within caliper), then report SMD balance | ALIASES: PSM, 倾向性评分, 倾向评分匹配, propensity score, 1:1匹配, 基线可比, 混杂控制, 匹配后均衡 | RETURNS: 匹配后样本与均衡性

Proposal / grant review / 标书评审 | USE WHEN: the user pastes a proposal or protocol and wants scoring, weaknesses and revision advice | ALIASES: 标书评审, 方案打分, 本子, 评审意见, proposal review, grant review, 专家怎么挑毛病 | RETURNS: 五维评分与修改建议

In-silico protein digestion / 蛋白酶解模拟 | USE WHEN: choose protease and list peptides for mass-spec sample prep | ALIASES: 蛋白酶解, 质谱前处理, 酶解肽段, digest, trypsin, 肽段清单 | RETURNS: 肽段清单

Protein enrichment / 蛋白富集分析 | USE WHEN: GO/KEGG enrichment for a protein list | ALIASES: 蛋白富集, protein enrichment, 蛋白GO, 蛋白通路 | RETURNS: 富集通路

Protein physicochemical properties / 蛋白理化性质 | USE WHEN: molecular weight, pI, GRAVY, instability index etc. from a protein sequence | ALIASES: 蛋白理化性质, 分子量, 等电点, pI, GRAVY, 疏水性, MW, protein properties | RETURNS: MW/pI/GRAVY 等

Post-translational modification prediction / 翻译后修饰分析 | USE WHEN: predict phosphorylation / glycosylation and other PTM sites | ALIASES: 翻译后修饰, 磷酸化位点, 糖基化, PTM, phosphorylation, modification sites | RETURNS: 修饰位点预测