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ai.nullary/nullary

By nullary.ai

Negative results intelligence for drug discovery — query measured failures via MCP.

Source code
Connect to ai.nullary/nullary
Checks passed
13 / 22

1 failed · 8 not measured

Median response
468 ms

Median of successful probes over 7 days

30-day uptime
Not measured

Share of countable probes over 30 days, including daily rollups. Auth challenges are excluded.

Discovered tools
35

Tool definitions returned by this server

Independent monitoring

Health & checks

Status history

Responded

The server completed its last measured handshake. This is an observation, not a guarantee.

Last checked
Check summary by test group
Test areaPassedFailedUnmeasured
ConnectionCan a client connect and discover tools?
500
Reliability & speedDoes it respond consistently and quickly?
004
Access & authenticationWhat is required to use this server?
102
Tool qualityAre the tool definitions usable by an agent?
400
Publisher identityCan the publisher be traced to its source?
312

Unmeasured means there is not enough evidence to decide. How these checks work

Inspect individual checks 22 recorded

Core

  • Pass
    Reachable

    Latest probe returned HTTP 200 in 468 ms.

  • Pass
    Valid handshake

    protocolVersion 2025-11-25, serverInfo.name Nullary.

  • Pass
    Lists tools

    tools/list returned 35 tools.

  • Pass
    Current protocol

    Negotiated 2025-11-25. The bar is 2025-06-18 or newer.

  • Pass
    HTTPS

    The endpoint URL is https.

Performance

  • Not measured
    Fast (p50)

    Median latency 468 ms over 1 samples in 7 days. The bar is 1000 ms. Need at least 5 samples.

  • Not measured
    Consistent (p95)

    95th percentile 468 ms over 1 samples in 7 days. The bar is 3000 ms. Need at least 20 samples.

  • Not measured
    Reliable (uptime)

    1 of 1 attempts returned a tool list in 30 days (100%). The bar is 99%. Need at least 30 samples.

  • Not measured
    Stable tool list

    Fewer than two successful probes in 30 days, so tool-list stability is not measured.

Access

  • Pass
    Open access

    tools/list succeeded with no credential, and the record declares none.

  • Not measured
    Standard auth

    Auth is not required, so the OAuth metadata check does not apply.

  • Not measured
    Free tier cited

    No publisher quote has been checked.

Tools

  • Pass
    Tools described

    Every tool description is at least 20 characters.

  • Pass
    Valid input schemas

    Every inputSchema is a JSON Schema object.

  • Pass
    Parameters documented

    172 of 172 parameters have a description (100%). The bar is 80%.

  • Pass
    Safety hints

    Every tool sets readOnlyHint or destructiveHint.

Publisher

  • Pass
    Verified namespace

    Listed in the Official MCP Registry.

  • Fail
    Website matches publisher

    The website host does not match the reverse-domain namespace.

  • Pass
    Source repo linked

    A repository URL is on file.

  • Not measured
    Repo owner matches

    This namespace is not an io.github login, so the owner comparison does not apply.

  • Pass
    Recently updated

    Updated 2026-05-25T00:44:06.690461Z, within 180 days.

  • Not measured
    Open-source licence

    The GitHub licence lookup has not returned an OSI result yet.

Start using ai.nullary/nullary

Connect to this server

Choose your client, copy the configuration, then enable the server in your client’s MCP settings.

Run this command in your terminal, then restart Claude Code.

Claude Code

claude mcp add --transport http ai-nullary-nullary https://mcp.nullary.ai/mcp

Capabilities

Tools 35

get_compound

A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.

Discovered
get_coverage

Per-modality and per-source coverage stats (honest Phase-1 numbers).

Discovered
get_finding_provenance

Full provenance + detail for a single finding by id.

Discovered
get_model_card

Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).

Discovered
get_target_landscape

Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).

Discovered
list_models

Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.

Discovered
list_top_targets

Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).

Discovered
search_adc_linker_failures

ADC failures attributed to linker chemistry.

Discovered
search_admet_failures

Small-molecule ADMET failures.

Discovered
search_admet_failures_all_modalities

ADMET failures across ALL modalities.

Discovered
search_ancestry_specific_failures

Ancestry-specific CRISPR failures.

Discovered
search_bispecific_format_failures

Bispecific format/engineering failures.

Discovered
search_developability_failures

Antibody developability failures.

Discovered
search_drug_drug_interaction_failures

Drug-drug interaction failures.

Discovered
search_failed_adcs

ADCs that failed at any stage.

Discovered
search_failed_bispecifics

Bispecifics that failed at any stage.

Discovered
search_failed_clinical_antibodies

Discontinued/terminated clinical antibodies.

Discovered
search_failed_essentiality_screens

Non-dependency / failed essentiality screens.

Discovered
search_failed_guides

Failed/ineffective CRISPR guides.

Discovered
search_failed_oligonucleotides

ASOs/siRNAs that failed engagement/developability.

Discovered
search_failed_peptide_therapeutics

Failed peptide therapeutics.

Discovered
search_failed_protacs

PROTACs that failed degradation/ternary/permeability.

Discovered
search_failed_replications

Findings that failed to replicate.

Discovered
search_failed_selectivity

Small molecules that failed selectivity.

Discovered
search_failed_vaccines

Failed/terminated vaccines (by pathogen/indication).

Discovered
search_inactive_compounds

Inactive small-molecule compound-target pairs.

Discovered
search_indication_history

ALL failed approaches for an indication across every modality.

Discovered
search_mechanism_failures

Approaches that failed for a mechanism (by target).

Discovered
search_oligo_delivery_failures

Oligonucleotide delivery failures.

Discovered
search_pathogen_history

Vaccine + antimicrobial + antibody failures for a pathogen.

Discovered
search_peptide_stability_issues

Peptide stability/half-life failures.

Discovered
search_protac_e3_issues

PROTAC E3-ligase recruitment / ternary failures.

Discovered
search_safety_failures

Clinical/preclinical safety failures across modalities.

Discovered
search_target_history

ALL failed approaches against a target across every modality.

Discovered
search_vaccine_immunogenicity_failures

Failed vaccine immunogen designs.

Discovered

Recent measurements

Probe history

View status
Latest stored probes. Raw probe rows are kept for 14 days.
CheckedResultResponseTools
Connected468 ms35

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